ATX-104

ATX-104 is a light-activated facial contouring agent, which is based on a proprietary technology co-developed by KYTHERA and Johns Hopkins University. ATX-104 is designed to be injected and shaped, and then polymerized by an external light source. During photopolymerization, the injected material is transformed from a viscous liquid into a cohesive, semi-solid that maintains its shape. The resulting implant maintains shape better and longer (enhanced persistence) in comparison to market leading dermal filling agents. In preclinical models, ATX-104 photochemistry, when combined with all tested commercially available fillers, dramatically improved the persistence and ability to maintain a contoured shape as compared with the filler alone.

Potential uses

Injectable dermal fillers have played an increasingly important role in nonsurgical facial rejuvenation and soft tissue augmentation. Physicians have advanced from the practice of line and wrinkle filling towards filling large facial areas to globally restore natural contours and re-establish a youthful appearance.

Soft tissue augmentation research is ongoing in many areas including the treatment of disfigurements caused by congenital deformities, surgery or traumatic injury; the treatment of patients suffering from HIV lipoatrophy; and vocal cord augmentation to treat paresis.

ATX-104, a light-activated facial contouring agent, has potential uses in facial sculpting, volume replacement to restore and create facial contours and many other areas of soft tissue augmentation.