ATX-202

ATX-202 is a polypeptide that promotes the synthesis of the skin pigment, melanin, by regulating melanocyte function. These attributes make it a viable candidate for pigmentation-related research. KYTHERA is currently studying ATX-202 in the treatment of the pigmentation disorder, vitiligo.

Potential uses

Vitiligo is a common disorder that affects approximately 1-4% of the world’s population.1 It is characterized by the formation of white spots on the skin that tend to enlarge over time. A pathological hallmark of vitiligo is the absence of melanocytes in the skin. Melanocytes, normally located in the basal layer of the epidermis, are cells that produce the pigment melanin, which gives skin its color. In addition to vitiligo, ATX-202 may also have applications to treat other pigmentation disorders.

 

1Ortonne, JP, Bose SK. Vitiligo. Where do we stand? Pigment Cell Res 1993;6:61-72